Intraocular lenses (IOLs) are artificial lenses which might be used for changing the pure lens of the attention. Mostly, they’re used to switch lenses which have been clouded by cataracts. Roughly 30 million cataract surgical procedures have been carried out worldwide in 2022.1 Yearly this quantity will increase as a result of growing prevalence of eye situations related to the getting old inhabitants, life-style modifications and different elements.
A number of forms of IOLs are used for cataract surgical procedure. Globally, cataracts are a serious contributor to visible impairment. In low and middle-income nations, cataracts are accountable for over 50% of blindness circumstances.2 The commonest IOL is the monofocal IOL, which permits for focus at a set distance. Different forms of IOLs, equivalent to multifocal and accommodative lenses, which permit the affected person to have totally different focusing powers inside the similar lens. Multifocal lenses have areas inside the lens that enable for viewing shut and distant objects. Accommodative lenses finest simulate the pure lens of the attention by benefiting from the pure musculature of the attention to bodily change the refractive properties of the IOL.
As per the “International Intraocular Lens Market Worth, 2019-2029” chart, the multifocal IOL market compromised greater than half of the full IOL market based mostly on the 2022 market worth.3 This pattern is predicted to be noticed over the forecast interval, with the multifocal lens market gaining market shares every year. Regardless of this quick development, multifocal IOL items composed not more than 15% of the full IOL items bought in 2022 globally. This disparity is as a result of excessive common promoting worth (ASP) of multifocal lenses.
In 2022, the ASP for multifocal IOLs have been nearly eight occasions larger in comparison with monofocal IOLs.3 It will stay one of many foremost elements limiting the excessive development of multifocal IOL over the forecast interval, regardless of its quite a few benefits. This text will focus on the principle driving elements for the continued worldwide development of IOL.
Ageing of the Inhabitants Driving IOL Market Development
Worldwide development in IOL might be primarily attributed to the getting old of the inhabitants. As world healthcare has improved, the common lifespan of the inhabitants has expanded. Whereas it is a constructive consequence, it additionally implies that people have the next probability of reaching an age the place they might encounter age-associated situations, equivalent to cataracts. Consequently, rise of an getting old inhabitants straight correlates with the rising incidence price of cataracts, together with the necessity to handle it.
Frequent age-related eye situations embody presbyopia, glaucoma, dry eyes, age-related muscular degeneration, cataracts and others. In line with the World Well being Group, a minimum of 2.2 billion folks have a close to or distance imaginative and prescient impairment with a minimum of 1 billion of those circumstances being preventable.4 The principle situation inflicting distance imaginative and prescient impairment or blindness are cataracts, which impacts round 95 million folks globally.4
Consequently, the necessity for reasonably priced and efficient therapy is crucial to cut back morbidity related to cataracts. Due to this fact, corporations should be ready to reply to the growing demand for cataract surgical procedures.
Numerous main rivals within the IOL market are benefiting from this market development, in addition to some newer rivals which might be bringing novel know-how into the market. The principle rivals within the world IOL market are Alcon, J&J Imaginative and prescient Care, and Bausch & Lomb.
Elevated Incidence of Eye Circumstances
Globally, the prevalence variety of cataracts elevated by nearly 130% from 1990 to 2019.5 This may be attributed to a number of elements. One such issue is life-style modifications. Particularly, elevated display screen time and publicity to digital gadgets contribute to earlier onset of imaginative and prescient issues which boosts the demand for IOL. Digital eye pressure (DES) encompasses a variety of ocular signs which come up from extended utilization of digital digital gadgets.
The COVID-19 pandemic’s lockdown measures curtailed outside actions for folks of all ages, resulting in elevated display screen time. Primarily based on the statistics, the prevalence of DES signs in kids grew to 55%.6 Sure research point out that blue gentle publicity emitted by digital screens might induce oxidative stress inside the lens of the attention, probably taking part in a job within the improvement of cataracts. Oxidative stress arises when there’s an imbalance between the manufacturing of reactive oxygen species (ROS) and the physique’s capability to counteract them. This type of oxidative injury is believed to contribute to a variety of eye-related situations, together with the formation of cataracts.7 It is very important notice that there’s nonetheless plenty of debate on this matter as some research recommend that elements aside from ultraviolet (UV) gentle publicity would possibly play a extra vital function.
Prevalence of Diabetes
In 2021, each 1 in 10 adults was dwelling with diabetes, which accounts for greater than 520 million folks.8 By 2045, this quantity is predicted to achieve 782 million in response to the Worldwide Diabetes Federation.8 People with diabetes have a notably elevated danger, starting from 2 to five time larger, of creating cataracts, which frequently manifest at an earlier stage of their lives.
There are a number of organic mechanisms that contribute to the elevated danger of creating cataracts. Mostly, elevated ranges of blood sugar in diabetes provoke a phenomenon referred to as glycation, whereby surplus sugar molecules bind to proteins inside the lens of the attention.9 This interplay leads to a change of the construction and performance of lens proteins, inducing a cloudy and fewer clear look. This opacity subsequently triggers the event of cataracts. Due to this fact, the growing prevalence of diabetes considerably impacts cataract surgical procedures.
Intraocular Lenses Analysis and Growth
Because the demand for IOL rises every year, there are quite a few scientific analysis research aiming at bettering the know-how. A particular space of analysis facilities on enhancing biocompatibility, reaching improved visible high quality and adjustability, minimizing surgical incisions and mitigating problems equivalent to posterior capsular opacification and ophthalmitis.10
Moreover, plenty of scientific analysis goals at advancing optics. This encompasses the creation of multifocal and accommodative IOLs, which permits people to attain readability of imaginative and prescient throughout totally different distances with out counting on eyeglasses. The customization of IOL is one other analysis space investigating personalised IOLs to cater to the distinct visible necessities of every affected person, thereby optimizing their imaginative and prescient after surgical procedure. Furthermore, ongoing research are delving into IOLs which might be modified after being implanted, permitting for exact changes to refine the affected person’s visible acuity.11
Closing Factors
The worldwide intraocular lens market has been evolving and rising dramatically up to now, and it’s anticipated to keep up development because the wants of the inhabitants improve. With the excessive price of most biomaterials, North America and Western Europe characterize the best share of the full market. Moreso, IOLs are slowly turning into extra prevalent throughout the globe. Alcon stays the main firm available in the market worldwide.
For additional insights and extra granular market information, please see the report Ophthalmic System Market Measurement, Share, and Tendencies Evaluation – International – 2023-2029 by iData Analysis.
In regards to the Authors
Kateryna Hronska is a senior analysis analyst at iData Analysis. She works on analysis tasks relating to the medical machine business, publishing the International Diagnostic and Interventional Ophthalmic System analysis report.
Kamran Zamanian, Ph.D., is CEO and founding accomplice of iData Analysis. He has spent over 20 years working available in the market analysis business with a dedication to the examine of medical gadgets used within the well being of sufferers everywhere in the globe.
About iData Analysis
For 19 years, iData Analysis has been a robust advocate for data-driven decision-making inside the world medical machine, dental, and pharmaceutical industries. By offering customized analysis and consulting options, iData empowers its purchasers to belief the supply of information and make essential strategic selections with confidence.
Citations
- Basaldua, B. (2023, March 3). The Way forward for Cataract Surgical procedure. iOR Companions | Workplace-Primarily based Surgical procedure.
- Tognetto, D., & Giglio, R. (2021, October 1). Synthetic Intelligence Functions and cataract administration: A scientific evaluate. Survey of Ophthalmology.
- iData Analysis Inc. International Diagnostic and Interventional Ophthalmic System Market – 2023. Printed ___ 2023. Accessed ___, 2023.
- World Well being Group. (n.d.). Vision Impairment and blindness. World Well being Group.
- Fang, R., Yu, Y.-F., Li, E.-J., Lv, N.-X., Liu, Z.-C., Zhou, H.-G., & Track, X.-D. (2022, November 12). International, regional, nationwide burden and gender disparity of cataract: Findings from the worldwide burden of illness examine 2019 – BMC public well being. BioMed Central.
- Kaur, Ok., Gurnani, B., & Nayak, S. (2022, October). Digital Eye strain- A complete evaluate. Ophthalmology and remedy.
- Nita, M., & Grzybowski, A. (2016). The function of the reactive oxygen species and oxidative stress within the pathomechanism of the age-related ocular illnesses and different pathologies of the anterior and posterior eye segments in adults. Oxidative medication and mobile longevity.
- Diabetes all over the world in 2021. IDF Diabetes Atlas. (n.d.).
- Kiziltoprak, H., Tekin, Ok., & Inanc, M. (2019, March 15). Cataract in diabetes mellitus. World journal of diabetes.
- Luo, C., Wang, H., & Chen, X. (2022, Could 23). Current advances of intraocular lens supplies and floor modification in cataract surgical procedure. Frontiers.
- Salerno, L. C., Tiveron, M. C., & Alió, J. L. (2017). Multifocal intraocular lenses: Sorts, outcomes, problems and find out how to clear up them. Taiwan journal of ophthalmology.
